ELK Biotechnology IGF-IIR rabbit pAb
IGF-IIR rabbit pAb는 인간 IGF2R 단백질을 인식하는 고품질 폴리클로날 항체로, WB, IF, ELISA에 적합합니다. 고순도 IgG 형태로 제공되며, 세포 내 Golgi 및 엔도솜 막 단백질 검출에 유용합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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- ES3999-xxxxx (2개 옵션)
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- pk
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ELK Biotechnology IGF-IIR rabbit pAb
제품 개요
IGF-IIR rabbit pAb는 인간 IGF2R(Cation-independent mannose-6-phosphate receptor)을 인식하는 폴리클로날 항체입니다. 다양한 응용 분야(WB, IF, ELISA)에 적합하며, 고감도 단백질 검출에 활용할 수 있습니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | IGF-IIR rabbit pAb |
| Alternative Names | IGF2R; MPRI; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ELISA: 1/10000 (다른 응용은 미시험) |
| Immunogen | Synthesized peptide derived from the C-terminal region of human IGF2R (AA range: 2251–2300) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 250 kDa |
| GeneID (Human) | 3482 |
| Human Swiss-Prot No | P11717 |
| Cellular Localization | Golgi apparatus membrane; Endosome membrane; Single-pass type I membrane protein. Mainly localized in the Golgi at steady state and not detectable in lysosome (PubMed:18817523). Colocalized with DPP4 in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including intracellular trafficking of lysosomal enzymes, activation of transforming growth factor beta, and degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been associated with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
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