ELK Biotechnology Integrin α4 rabbit pAb
Integrin α4 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트에 반응하며 세포막 단백질 검출에 적합. ITGA4 단백질 연구 및 염증성 질환 관련 연구에 활용 가능.
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Integrin α4 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Integrin α4 rabbit pAb |
| Alternative Names | ITGA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 IHC-p: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from the internal region of human ITGA4. (AA range: 571–620) |
| Host | Rabbit |
| Storage | -20°C for 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 120 kDa |
| Gene ID (Human) | 3676 |
| Human Swiss-Prot No. | P13612 |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
Integrin subunit alpha 4 (ITGA4) is a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn’s disease, and inflammatory bowel disease. Alternative splicing results in multiple transcript variants.
(Provided by RefSeq, Oct 2015)
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