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Thermo Fisher Scientific CD304 (Neuropilin-1) Monoclonal Antibody (3DS304M), PE, eBioscience

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마우스 CD304(Neuropilin-1)을 인식하는 단클론 항체로, 형광 표지 PE가 결합되어 있습니다. Flow Cytometry에 최적화되어 있으며, Treg, NKT, DC 등 다양한 세포에서 Neuropilin-1 발현 분석에 사용됩니다. 고순도 정제 및 4°C 보관 권장.

카탈로그번호: 12-3041-82
브랜드: Thermo Fisher Scientific
카테고리: Monoclonal Antibodies
판매단위: pk

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Thermo Fisher Scientific 12-3041-82 CD304 (Neuropilin-1) Monoclonal Antibody (3DS304M), PE, eBioscience 100 ug pk판매 단위 pk ·

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570,900원VAT 포함 627,990원

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Thermo Fisher Scientific · Thermo Fisher Scientific CD304 (Neuropilin-1) Monoclonal Antibody (3DS304M), PE, eBioscience

Applications and Tested Dilution

Application: Flow Cytometry (Flow)
Tested Dilution: 0.125 µg/test
Publications: View 3 publications

Product Specifications

항목	내용
Species Reactivity	Mouse
Published Species	Mouse
Host / Isotype	Rat / IgG2a, kappa
Recommended Isotype Control	Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™
Class	Monoclonal
Type	Antibody
Clone	3DS304M
Conjugate	PE
Excitation / Emission Max	565 / 576 nm
Form	Liquid
Concentration	0.2 mg/mL
Purification	Affinity chromatography
Storage Buffer	PBS, pH 7.2
Contains	0.09% sodium azide
Storage Conditions	4°C, store in dark, DO NOT FREEZE
Shipping Conditions	Ambient (domestic); Wet ice (international)
RRID	AB_2572603

Additional Formats

APC
eFluor 450
PE-Cyanine7
PE-eFluor 610
PerCP-eFluor 710
Super Bright 436
Super Bright 600
Super Bright 780
Request custom conjugation

Product Specific Information

The monoclonal antibody 3DS304M recognizes mouse CD304 (Neuropilin-1), a type I transmembrane glycoprotein expressed on regulatory T cells (Treg), NKT cells, dendritic cells, certain stem cells, neurons, endothelial cells, and some neoplastic cells.

Neuropilin-1, in complex with plexins, acts as a co-receptor for type 3 semaphorins in neurons and participates in angiogenesis as part of the VEGF receptor complex. In mice, Neuropilin-1 is expressed on thymus-derived natural Treg cells but not on peripherally induced Treg cells. Transient expression has been observed on recently activated non-regulatory T cells.

Neuropilin-1 serves as a marker for recent thymic emigrants in mouse iNKT cells and forms a complex with TGF beta receptors, activating latent TGF beta and enhancing Smad2/3 signaling.

This antibody recognizes both formaldehyde-fixed and methanol-treated epitopes.

Applications Reported: Flow cytometric analysis
Applications Tested: Flow cytometric analysis of mouse splenocytes
Recommended Usage: ≤ 0.125 µg per test (100 µL final volume)
Excitation: 488–561 nm
Emission: 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered

Target Information

Neuropilin-1 (NRP1) is a 923-amino-acid membrane-bound co-receptor belonging to the neuropilin family. It contains two CUB domains, two F5/8 type C domains, and a MAM domain. Neuropilin-1 forms heterodimers with Neuropilin-2 (NRP2) and binds plexins (PLXNB1) to form semaphorin receptors.

Primarily expressed in the nervous system, Neuropilin-1 is involved in:

Cardiovascular development and angiogenesis
Axon guidance and neuronal circuit formation
Cell survival and migration
Organogenesis outside the nervous system

It functions as a receptor for both semaphorins and VEGF, regulating VEGF-induced angiogenesis. Neuropilin-1 expression has been linked to aggressive prostate carcinoma and breast cancer progression.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.