Thermo Fisher Scientific CD100 Polyclonal Antibody

Thermo Fisher Scientific CD100 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500 dilution

Product Specifications

Product Specific Information

PA1-4202 detects CD100 in human samples.
It has been successfully used in Western blot procedures.
By Western blot, this antibody detects a ~158 kDa protein representing CD100 in transfected CHO cells.
The immunogen is a synthetic peptide corresponding to residues K(777) P K S D F C D R E Q S(788) of human CD100.

Target Information

Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development.
CD100 (also known as semaphorin 4D), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro.
CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and downregulating CD23 expression.
CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling.
CD100 is expressed on resting and PHA-stimulated T cells. The protein is weakly expressed on NK cells, EBV-transformed B cells, monocytes, and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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