Thermo Fisher Scientific POLR3E Polyclonal Antibody
POLR3E 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제됨. 인간 시료 반응성, 고순도 PBS 버퍼(40% 글리세롤) 기반 액상 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human POLR3E. Recombinant protein control fragment (Product #RP-98554). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645770 |
Product Specific Information
Immunogen sequence:
FVMWKFTQSR WVVRKEVATV TKLCAEDVKD FLEHMAVVRI NKGWEFILPY DGEFIKKHPD VVQRQHMLWT GIQAKLEKVY NLVKETMPKK PDAQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 93%
Target Information
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Specific peripheral component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters.
Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.
Acts as a nuclear and cytosolic DNA sensor involved in innate immune response.
Can sense non-self dsDNA that serves as a template for transcription into dsRNA.
The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB through the RIG-I pathway.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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