Thermo Fisher Scientific GUCY1B3 (GCS-b-1) Monoclonal Antibody (GC11)
GUCY1B3 단백질을 인식하는 Thermo Fisher Scientific의 GC11 단클론 항체로, IHC(P) 실험에 적합합니다. 인간 시료 반응성을 가지며, 단백질 A로 정제된 액상 비결합형 항체입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GC11 |
| Immunogen | A synthetic peptide of C-terminus of human GUCY1B3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Fetal lung tissue lysate
- Cellular location: Cytoplasm
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase:
- Soluble form (GCS or sGC): Acts as receptors for nitric oxide
- Membrane-bound receptor form (GC): Peptide hormone receptors
The GC-C protein is composed of:
- An extracellular domain
- A single transmembrane domain
- A cytoplasmic region consisting of a kinase-like domain and a catalytic domain
It is expressed as two differentially glycosylated forms:
- 130 kDa precursor form: Present in the endoplasmic reticulum
- 145 kDa form: Present on the plasma membrane
Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heat-stable enterotoxins secreted by some pathogenic E. coli strains, causing severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, modulating renal function in response to oral salt load.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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