Thermo Fisher Scientific CD9 (TSPAN29) (Motility-Related Protein-1) Monoclonal Antibody (CD9, 2343)

Thermo Fisher Scientific CD9 (TSPAN29) Monoclonal Antibody (CD9, 2343)

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
• Flow Cytometry (Flow): 0.5–1 µg/10^6 cells

Product Specifications

Product Specific Information

Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at room temperature for 20 minutes.

Target Information

CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophils, stimulated T lymphocytes, and by neurons and glial cells in the peripheral nervous system.
CD9 belongs to the tetraspanin family, which spans the membrane four times. In pre-B cells and platelets, CD9 regulates cell activation and aggregation, possibly through an association with integrins CD41/CD61 (GPIIb/GPIIIa).
It is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion. CD9 plays roles in cell attachment and proliferation and is necessary for the association of heterologous MHC II molecules on dendritic cell membranes, which is important for effective T-cell stimulation.
Expression of CD9 is critical for the suppression of cancer cell motility and metastasis and is considered a metastasis suppressor in solid tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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