Thermo Fisher Scientific KMT2D Monoclonal Antibody (3C8E11)
인간 KMT2D 단백질을 인식하는 마우스 단클론 항체로, Western blot, Flow cytometry, ELISA에 사용 가능. 고순도 Protein G 정제, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Flow Cytometry (Flow)
- Tested Dilution: 1:200–1:400
ELISA
- Tested Dilution: 1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3C8E11 |
| Immunogen | Purified recombinant fragment of human KMT2D (AA: 445–599) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091334 |
Target Information
KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me serves as a specific tag for epigenetic transcriptional activation. KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription. It is involved in chromatin organization, chromatin silencing, oocyte growth, oogenesis, and positive regulation of cell proliferation. Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1), resulting in congenital mental retardation syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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