Thermo Fisher Scientific CD44 Monoclonal Antibody (W4/86)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: Tonsil
• Cellular location: Membrane

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.
CD44 functions as a receptor for hyaluronic acid (HA) and participates in cell-cell interactions, adhesion, and migration. It is involved in lymphocyte activation, recirculation, and homing. CD44 expression may be up-regulated in certain carcinomas and is associated with metastatic potential.
It is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, while peripheral B and T cells can upregulate CD44 in response to stimulation.
CD44 transcripts undergo complex alternative splicing, resulting in many functionally distinct isoforms. This splicing contributes to structural and functional diversity. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus, and CD44 may play roles in tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.