Thermo Fisher Scientific SDHD Polyclonal Antibody
Human SDHD 단백질을 인식하는 Rabbit Polyclonal Antibody로 다양한 응용 분야(WB, IHC, ICC/IF, Flow)에 사용 가능. KLH 결합 합성 펩타이드로 면역원 제작. 고순도 Protein A 및 항원 친화 크로마토그래피 정제. 연구용으로만 사용.
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- PA571645
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 13–42 amino acids from the N-terminal region of human SDHD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2717499 |
Target Information
The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH).
Mutations in SDHD often lead to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also acts as a tumor-suppressor gene.
In a family with a nonsense mutation (R22X) in the SDHD gene, loss of heterozygosity was found in paragangliomas, and the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished.
Furthermore, high levels of angiogenic factors EPAS1 and VEGF were observed, potentially stimulating tumor growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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