Thermo Fisher Scientific USP37 Polyclonal Antibody
Human USP37 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 IHC-Paraffin 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 0.2 mg/mL 농도의 액상 형태. Gorilla 및 Chimpanzee에 교차 반응 예측. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 930 and the C-terminus (residue 979) of Human Ubiquitin Specific Peptidase 37 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Gorilla and Chimpanzee
Target Information
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry.
Specifically mediates deubiquitination of Lys-11-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex.
Also mediates deubiquitination of Lys-48-linked polyubiquitin chains in vitro.
Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, preventing degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315).
Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: IHC-00509_USP37_Q86T82-1_Rabbit.svg, IHC-00509_USP37_Q86T82-1_Rabbit_PDP.jpeg)
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