Thermo Fisher Scientific CDC73 Recombinant Rabbit Monoclonal Antibody (1B8Q1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

1B8Q1

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human HRPT2 CDC73. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDC73,uniProtId:Q6P1J9-1,ncbiNodeId:9606,antigenRange:300-400,antigenLength:531,antigenImageFileName:MA5-55469_CDC73_Q6P1J9-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55469_CDC73_Q6P1J9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: GKEETEGFKI DTMGTYHGMT LKSVTEGASA RKTQTPAAQP VPRPVSQARP PPNQKKGSRT PIIIIPAATT SLITMLNAKD LLQDLKFVPS DEKKKQGCQR E

Target Information

Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. Cdc73 is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1 and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.