Thermo Fisher Scientific UPF1 Polyclonal Antibody
UPF1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot에 최적화되어 있으며, 인간 시료에 반응. 액상 형태로 제공되며, 고순도 친화 크로마토그래피로 정제됨. 연구용으로만 사용 가능.
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Thermo Fisher Scientific UPF1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human UPF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2606238 |
Product Specific Information
- Peptide sequence: RGTPKGKTGR GGRQKNRFGL PGPSQTNLPN SQASQDVASQ PFSQGALTQG
- Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 79%
Horse: 93%
Human: 100%
Mouse: 93%
Rat: 93%
Zebrafish: 83%
Target Information
Upf1 is an active component in nonsense-mediated decay (NMD), an mRNA surveillance mechanism in eukaryotic cells that degrades mRNAs containing premature termination codons. It functions as an ATP-dependent RNA helicase in the cytoplasm and is also a component of cytoplasmic P-bodies. Phosphorylation of Upf1 mediates translation repression associated with NMD, facilitating mRNA accessibility to the NMD machinery. Other active NMD components, Upf2 and Upf3, exhibit perinuclear and nucleocytoplasmic localization, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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