Thermo Fisher Scientific SLC22A17 Monoclonal Antibody (OTI2D6)
Human SLC22A17 단백질을 인식하는 Mouse monoclonal antibody로, Western blot과 IHC(Paraffin)에 1:500 희석 비율로 사용 가능. Unconjugated 형태이며, 고순도 Affinity Chromatography 정제. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:500
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 241–300 of SLC22A17 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725364 |
Target Information
The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins mainly expressed in kidney and liver. They contain 12 predicted alpha-helical transmembrane domains and a large extracellular loop between TMDs 1 and 2.
Transporters of the SLC22 family function as:
- Uniporters mediating facilitated diffusion (OCTs)
- Anion exchangers (OAT1, OAT3, URAT1)
- Na(+)/l-carnitine cotransporters (OCTN2)
These proteins are involved in absorption and excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart.
Mutations in the Slc22 family may cause diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia, and may affect drug absorption or excretion.
Recent studies show that Slc22A17, acting as a receptor for Lipocalin 2, is highly expressed in hematopoietic stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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