Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI6E4), TrueMAB
인간 ABCB1 단백질을 인식하는 마우스 단클론 항체입니다. IHC(P)에서 1:150 희석으로 검증되었습니다. 약물 내성 관련 연구 및 P-glycoprotein 표적 분석에 적합합니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6E4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The membrane-associated protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across cellular membranes and are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is part of the MDR/TAP subfamily, which is involved in multidrug resistance. It acts as an ATP-dependent drug efflux pump for xenobiotic compounds, contributing to decreased drug accumulation in multidrug-resistant cells and mediating resistance to anticancer drugs. It also functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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