Thermo Fisher Scientific SGMS1 Polyclonal Antibody
SGMS1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA에 적합합니다. 인간 및 랫트 시료에 반응하며, Affinity Chromatography로 정제된 액상 제품입니다. 골지체 막 단백질 검출 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–134 of human SGMS1 (NP_6715121) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.9 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805950 |
Product Specific Information
Immunogen sequence:
MKEVVYWSPK KVADWLLENA MPEYCEPLEH FTGQDLINLT QEDFKKPPLC RVSSDNGQRL LDMIETLKME HHLEAHKNGH ANGHLNIGVD IPTPDGSFSI KIKPNGMPNG YRKEMIKIPM PELERSQYPM EWGK
Positive Samples: A-549
Cellular Location: Golgi apparatus membrane, multi-pass membrane protein
Target Information
SGMS1 is a bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG), and vice versa. The reaction direction depends on the relative concentrations of DAG and ceramide. It directly recognizes the choline head group on the substrate and requires two fatty chains on the choline-P donor molecule for efficient recognition. It may not function strictly as a sphingomyelin synthase and is inhibited by bacterial PC-phospholipase C inhibitor D609.
Localized to the Golgi apparatus membrane as a multi-pass membrane protein. Possibly expressed in brain, heart, kidney, liver, muscle, and stomach.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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