Thermo Fisher Scientific PDE6G Monoclonal Antibody (OTI1H7), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Target Information

The second messengers cAMP and cGMP are key regulatory molecules involved in a wide variety of signal transduction pathways. Their levels are controlled by synthesis through nucleotide cyclases and hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that convert cyclic nucleotides to their corresponding nucleoside monophosphates.
PDE6 acts as the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. It consists of multiple subunits: rod and cone-specific catalytic subunits (alpha’, alpha, and beta), an inhibitory gamma subunit, and a delta subunit of unknown function. The catalytic core includes alpha’/alpha’ homodimers in cones and alpha/beta heterodimers in rods. The C-terminus of both catalytic and inhibitory subunits undergoes methylation, myristoylation, and prenylation, essential for proper complex assembly and membrane association.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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