Thermo Fisher Scientific Myeloperoxidase Recombinant Rabbit Monoclonal Antibody (0J10S7)
Recombinant rabbit monoclonal antibody (clone 0J10S7) targeting human Myeloperoxidase (MPO). Validated for WB, IHC (Paraffin), and ELISA. High purity via affinity chromatography. Supplied in PBS with BSA and glycerol for stability.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 0J10S7 |
| Immunogen | Synthetic peptide corresponding to amino acids 646–745 of human Myeloperoxidase (MPO) (NP_0002411) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2911793 |
Product Specific Information
- Positive test controls: HL-60 cells
- Immunogen sequence:
GVSEPLKRKG RVGPLLACII GTQFRKLRDG DRFWWENEGV FSMQQRQALA QISLPRIICD NTGITTVSKN NIFMSNSYPR DFVNCSTLPA LNLASWREAS
Target Information
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation and is a major component of neutrophil azurophilic granules. It is produced as a single-chain precursor that is cleaved into light and heavy chains, forming a tetramer (2 light + 2 heavy chains). MPO catalyzes the formation of hypohalous acids, key to neutrophil microbicidal activity.
Associated diseases include Myeloperoxidase Deficiency and Familial Alzheimer’s Disease type 1.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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