Thermo Fisher Scientific ROBO1 Monoclonal Antibody (1F8)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
DGVLVSTQDS RIKQLENGVL QIRYAKLGDT GRYTCIASTP SGEATWSAYI EVQEFGVPVQ PPRPTDPNLI PSAPSKPEVT DVSRNTVTLS WQPNLNSGA

Target Information

Specialized cells at the midline, which separates the left and right halves of the CNS, have roles in directing growth cone behavior. In vertebrates, midline cells produce guidance cues such as nectins and slit, which act as attractants and repellents. Robo acts as a receptor for the repellent Slit and functions cell-autonomously. Non-crossing axons express high levels of Robo, whereas crossing axons express low levels before reaching the midline and high levels after crossing. Robo1 and Robo2 are human homologs of the Drosophila protein Roundabout. Robo1 is also homologous to the C. elegans gene sax3, and Robo2 to the zebrafish gene astray.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.