Thermo Fisher Scientific ALX3 Monoclonal Antibody (1F1)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
KSKKRRNRTT FSTFQLEELE KVFQKTHYPD VYAREQLALR TDLTEARVQV WFQNRRAKWR KRERYGKIQE GRNPFTAAYD ISVLPRTDSH PQLQNSLWAG

Target Information

Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis.
The homeodomain transcription factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predominant ALX3 expression in brain tissue.

The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression.

Alx3 (-) mice lack a phenotype distinct from wild-type mice; however, Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest-derived skull structures.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.