Thermo Fisher Scientific GATA3 Monoclonal Antibody (OTI5F1), TrueMAB
Human GATA3 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot에 최적화됨. TrueMAB 형식으로 높은 특이성과 재현성을 제공. 연구용으로 T-cell 관련 유전자 조절 연구에 활용 가능. -20°C 보관, PBS/BSA/glycerol buffer 포함.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F1 |
| Immunogen | Human recombinant protein fragment (aa 155–443 of human GATA3) produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3 contains a zinc finger domain and is abundantly expressed in the T-lymphocyte lineage, participating in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene, which comprises six exons distributed over 17 kb of DNA. Its two zinc fingers are encoded by separate exons conserved with GATA1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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