Thermo Fisher Scientific HSC70 Recombinant Rabbit Monoclonal Antibody (23GB2675)
HSC70 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot에 최적화되어 있으며 인간, 생쥐, 랫드 시료에 반응. 고순도 친화 크로마토그래피 정제, PBS/glycerol 완충액에 보존. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
Tested Application
- Western Blot (WB): 1:1,000–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB2675 |
| Immunogen | A synthesized peptide derived from human Hsc70 (600–646 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The HSP70 family is a group of highly conserved proteins induced by various biological stresses, including heat stress, across all organisms studied.
Human HSP70 family members include:
- HSP70: Strongly inducible in all organisms and constitutively expressed in primate cells
- HSP72: Induced exclusively under stress conditions
- HSC70 (Cognate Protein): A constitutively expressed 72 kDa protein involved in uncoating of clathrin-coated vesicles
- GRP78 (BiP): A 78 kDa glucose-regulated protein localized in the endoplasmic reticulum
- p75 (HSP75): A 75 kDa protein found within mitochondria
HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is constitutively expressed and slightly heat-inducible.
It binds to clathrin light chains to promote uncoating, associates with the cytoskeleton to facilitate rearrangements, and has been shown to stimulate lysosomal degradation of intracellular proteins while modulating folding of mitochondrial precursor proteins in vitro.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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