Thermo Fisher Scientific HSC70 Recombinant Rabbit Monoclonal Antibody (23GB2675)

Applications

Tested Application

• Western Blot (WB): 1:1,000–1:5,000

Product Specifications

Target Information

The HSP70 family is a group of highly conserved proteins induced by various biological stresses, including heat stress, across all organisms studied.
Human HSP70 family members include:

• HSP70: Strongly inducible in all organisms and constitutively expressed in primate cells
• HSP72: Induced exclusively under stress conditions
• HSC70 (Cognate Protein): A constitutively expressed 72 kDa protein involved in uncoating of clathrin-coated vesicles
• GRP78 (BiP): A 78 kDa glucose-regulated protein localized in the endoplasmic reticulum
• p75 (HSP75): A 75 kDa protein found within mitochondria

HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is constitutively expressed and slightly heat-inducible.
It binds to clathrin light chains to promote uncoating, associates with the cytoskeleton to facilitate rearrangements, and has been shown to stimulate lysosomal degradation of intracellular proteins while modulating folding of mitochondrial precursor proteins in vitro.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.