Thermo Fisher Scientific CDKN2A/p19ARF Polyclonal Antibody
마우스 및 랫트 CDKN2A/p19ARF 단백질을 인식하는 Rabbit Polyclonal 항체. IHC, ICC/IF, ELISA 등 다양한 응용에 사용 가능. Protein A로 정제된 고순도 항체로 안정적인 액상 형태 제공. 종양 억제 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from mouse CDKN2A/p19ARF (amino acids 65–169) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF.
Both act as inhibitors of cell proliferation through different mechanisms.
p19ARF functions within a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals.
Mice lacking the p19ARF gene develop a broad spectrum of tumors, highlighting its role as a critical tumor suppressor.
Additionally, p19ARF helps prevent transforming signals from various oncoproteins via the p53 regulatory loop, emphasizing its importance in cell cycle control and tumor suppression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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