Thermo Fisher Scientific CD30 Recombinant Mouse Monoclonal Antibody (Ki-3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody binds specifically to CD30.

Target Information

CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. It was first identified as a surface antigen on Hodgkin’s and Reed-Sternberg cells using the monoclonal antibody Ki-1.
The ligand for CD30 is CD30L (CD153), and their interaction mediates various cellular processes including proliferation, activation, differentiation, and apoptosis.
CD30 plays a crucial role in the pathophysiology of Hodgkin’s disease and other CD30-positive lymphomas. It also functions as a costimulatory molecule during thymic negative selection.

CD30 expression is observed in:

• Hodgkin’s and Reed-Sternberg cells
• Certain non-Hodgkin’s lymphomas (e.g., Burkitt’s lymphoma)
• Virus-infected T and B cells
• Activated normal T and B cells

In T cells, CD30 is expressed on subsets that produce Th2-type cytokines and on CD4+/CD8+ thymocytes co-expressing CD45RO and IL4 receptor.
The soluble form (sCD30) serves as a marker of Th2 immune response.
CD30 interacts with TRAF2 and TRAF5, leading to NF-κB activation and promoting apoptosis regulation, limiting autoreactive CD8 effector T cell proliferation, and protecting against autoimmunity.
Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
CD30 is expressed by mononuclear cells in Hodgkin’s lymphoma, Reed-Sternberg cells, and most Anaplastic Large Cell Lymphomas (ALCL), as well as in embryonal carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.