Thermo Fisher Scientific TMPRSS6 Polyclonal Antibody
TMPRSS6 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 시료에 반응합니다. Western blot과 IHC에 사용 가능하며, Affinity Chromatography로 정제되었습니다. PBS buffer에 보관되며, 연구용으로 적합합니다.
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- PA543989
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human TMPRSS6 (aa 71–120) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2606885 |
Product Specific Information
Peptide sequence:
LLWYFLGYKA EVMVSQVYSG SLRVLNRHFS QDLTRRESSA FRSETAKAQK
Sequence homology:
Cow: 100%
Dog: 93%
Guinea Pig: 86%
Horse: 100%
Human: 100%
Mouse: 100%
Pig: 100%
Rat: 100%
Target Information
TMPRSS6 is a serine protease that hydrolyzes various proteins including type I collagen, fibronectin, and fibrinogen. It can activate urokinase-type plasminogen activator with low efficiency and may play a specialized role in matrix remodeling processes in the liver. TMPRSS6 is also required to sense iron deficiency, and its overexpression suppresses activation of the HAMP promoter. The encoded protein is a type II transmembrane serine proteinase found on the cell surface and may be involved in liver matrix remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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