Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI1E2), TrueMAB
인간 N4BP2L2 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot에 적합합니다. 고순도 친화 크로마토그래피 정제 제품이며 액상 형태로 제공됩니다. PBS/BSA/glycerol 완충액에 보존되어 안정적인 장기 저장이 가능합니다.
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Thermo Fisher Scientific N4BP2L2 Monoclonal Antibody (OTI1E2), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E2 |
| Immunogen | Full length human recombinant protein of human N4BP2L2 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
N4BP2L2 (NEDD4-binding protein 2-like 2), also known as PFAAP5 (phosphonoformate immuno-associated protein 5), is a 583 amino acid nuclear protein potentially involved in transcriptional regulation. N4BP2L2 is phosphorylated on Ser 199 in response to DNA damage, likely by ATM or ATR. It is primarily expressed in bone marrow and is dramatically down-regulated after exposure to arsenic compounds, preceding neutropenia. PFAAP5 interacts with Gfi-1 and Neutrophil Elastase, proteins implicated in neutropenia disorders. Defects in the ELA2 gene encoding Neutrophil Elastase cause cyclic haematopoiesis, leading to decreased neutrophil counts and increased susceptibility to opportunistic infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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