Thermo Fisher Scientific HIPPI Polyclonal Antibody
Human HIPPI 단백질을 인식하는 Rabbit Polyclonal Antibody. IHC(P)에서 1:50~1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품. 단기 4°C, 장기 -20°C 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IFT57. Recombinant protein control fragment (Product #RP-96303) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790431 |
Product Specific Information
Immunogen sequence:
EGTGEVVLER GPGAAYHMFV VMEDLVEKLK LLRYEEEFLR KSNLKAPSRH YFALPTNPGE QFYMFCTLAA WLINKAGRPF EQPQEYDDPN
Target Information
HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, as cilia are required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruitment of caspase-8 (CASP8) and triggering apoptosis.
HIPPI can bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8, and CASP10, suggesting a possible transcription regulatory role, though its relevance remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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