Thermo Fisher Scientific PODN Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, Jurkat
• Predicted reactivity: Human (99%), Mouse (95%), Bovine (92%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Non-collagenous proteins of the small leucine-rich repeat (SLR) protein family are important components of the extracellular matrix, which regulates cell proliferation, differentiation, adhesion, and migration.
Podocan (PCAN, SLRR5A, PODN) is a 613-amino-acid secreted protein of the small leucine-rich proteoglycan (SLRP) family, class V subfamily. It is expressed in kidney, heart, liver, pancreas, and vascular smooth muscle cells.
Podocan exists as three alternatively spliced isoforms containing twenty LRRs, a unique N-terminal cysteine-rich cluster, and a highly acidic C-terminal domain. It is a glycoprotein with N-linked oligosaccharides possibly involved in growth regulation in cardiovascular tissues.
Encoded by a gene located on human chromosome 1, Podocan interacts with type I collagen (COL1).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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