Thermo Fisher Scientific POLR3G Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total RPC7.

Target Information

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
POLR3G is a specific peripheral component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs. It may direct RNA Pol III binding to the TFIIIB-DNA complex via interactions between TFIIIB and POLR3F.
POLR3G may be involved in recruitment and stabilization of the subcomplex within RNA polymerase III or in stimulating catalytic functions of other subunits during initiation.
It plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, acting as a nuclear and cytosolic DNA sensor involved in innate immune response.
POLR3G can sense non-self dsDNA serving as template for transcription into dsRNA. The resulting non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB through the RIG-I pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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