Thermo Fisher Scientific Human AXIN2 Synthetic Peptide
인간 AXIN2 단백질의 C-말단 20개 아미노산 서열에 해당하는 합성 펩타이드. 항체 PA5-21093의 블로킹 펩타이드로 사용 가능. Wnt 신호 경로 연구 및 베타카테닌 안정성 조절 연구에 적합. 연구용 시약으로만 사용.
- 카탈로그번호
- PEP1207
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 20 amino acids near the carboxy terminus of human AXIN2.
PEP-1207 can be used as a blocking peptide with polyclonal antibody PA5-21093.
Target Information
The Axin-related protein, Axin2, plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, similar to its rodent homologs (mouse conductin/rat axil).
In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin.
Deregulation of beta-catenin is an important event in the genesis of various malignancies. The AXIN2 gene is mapped to 17q23-q24, a region frequently showing loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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