Thermo Fisher Scientific Fetal Hemoglobin Monoclonal Antibody (HBF-1), APC

Thermo Fisher Scientific Fetal Hemoglobin Monoclonal Antibody (HBF-1), APC

Applications

• Immunocytochemistry (ICC/IF)
  Tested Dilution: –
  View 2 publications
• Flow Cytometry (Flow)
  Tested Dilution: Assay-dependent
  View 13 publications

Product Specifications

Additional Formats

• FITC
• PE
• Request custom conjugation

Target Information

Hemorrhage of cells from an Rh⁺ fetus into the circulation of an Rh⁻ mother may result in the formation of Rh-reactive antibodies in the mother. Rh hemolytic anemia in a subsequent Rh⁺ fetus may result from placental transfer of antibodies formed in the mother to the fetus. Although the volume of fetal erythrocytes found in the maternal circulation during pregnancy and immediately post-partum is reported to be small and of uncertain clinical significance in many cases, substantial hemorrhage may result from a number of causes including fetal or maternal trauma and placental defects.

Erythrocytes containing fetal hemoglobin may be found in individuals of any age, but with lower amounts of fetal hemoglobin compared to fetal red cells. These cells are termed F cells. High levels of F cells may also exist in adults with a heterogeneous group of genetic disorders of uncertain etiology, referred to as Hereditary Persistence of Fetal Hemoglobin (HPFH). Other clinical conditions causing significant levels of anemia may also result in elevated levels of F cells, such as sickle cell anemia and thalassemia major.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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