Thermo Fisher Scientific SCN4B (extracellular) Polyclonal Antibody
SCN4B 단백질의 세포외 영역을 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 동결건조 형태로 제공되며 -20°C 보관. SCN4B 관련 연구 및 전압 의존성 나트륨 채널 기능 분석에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:800 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide (C)KNDKSDPKVRVKDD, corresponding to amino acid residues 85–98 of rat NaV beta4 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.85 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2736571 |
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitute using 50 µL deionized water.
Target Information
The SCN4B protein modulates channel gating kinetics. It causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation.
SCN4B is highly expressed in dorsal root ganglia, and at lower levels in brain, spinal cord, skeletal muscle, and heart.
Defects in SCN4B are associated with long QT syndrome type 10 (LQT10) [MIM:611819], a heart disorder characterized by prolonged QT interval and polymorphic ventricular arrhythmias that can lead to syncope or sudden death during exercise or emotional stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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