Thermo Fisher Scientific COX11 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human COX11. Recombinant protein control fragment (Product #RP-100211). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:COX11,uniProtId:Q9Y6N1-1,ncbiNodeId:9606,antigenRange:192-274,antigenLength:276,antigenImageFileName:PA5-60591_COX11_Q9Y6N1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-60591_COX11_Q9Y6N1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2640087

Product Specific Information

Immunogen sequence: DKPVIGISTY NIVPFEAGQY FNKIQCFCFE EQRLNPQEEV DMPVFFYIDP EFAEDPRMIK VDLITLSYTF FEAKEGHKLP VPG

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 95%.

Target Information

Cytochrome c oxidase (COX) is the terminal enzyme in the electron transfer chain, functioning as a transmembrane proton pump that builds an electrochemical gradient with chemical energy from the reduction of O2. Cytochrome c oxidase assembly protein COX11 is an intracellular mitochondrial membrane protein necessary for the construction of an active COX complex. COX11 contains a single transmembrane helix downstream of the N-terminal, mitochondrial targeting sequence and a C-terminal Cu(I)-binding domain. The assembly of COX requires the delivery of metal cofactors. Along with COX12 and SCO1/2, COX11 acts as a metal ion chaperone necessary for copper insertion into CuA and CuB redox-active copper centers of COX in eukaryotes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.