Thermo Fisher Scientific COX11 Polyclonal Antibody
인간 COX11 단백질에 특이적인 Thermo Fisher Scientific의 폴리클로날 항체입니다. 면역조직화학(IHC)에서 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS와 글리세롤 버퍼에 보관되며 연구용으로 적합합니다.
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Thermo Fisher Scientific COX11 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:20–1:50 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human COX11 (Product #RP-100211) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640087 |
Product Specific Information
Immunogen sequence:
DKPVIGISTY NIVPFEAGQY FNKIQCFCFE EQRLNPQEEV DMPVFFYIDP EFAEDPRMIK VDLITLSYTF FEAKEGHKLP VPG
Ortholog sequence identity:
- Mouse: 96%
- Rat: 95%
Target Information
Cytochrome c oxidase (COX) is the terminal enzyme in the electron transfer chain, functioning as a transmembrane proton pump that builds an electrochemical gradient using the reduction of O₂.
Cytochrome c oxidase assembly protein COX11 is an intracellular mitochondrial membrane protein required for the construction of an active COX complex. It contains a single transmembrane helix downstream of the N-terminal mitochondrial targeting sequence and a C-terminal Cu(I)-binding domain.
COX assembly requires the delivery of metal cofactors, and COX11 acts as a metal ion chaperone necessary for copper insertion into CuA and CuB redox-active copper centers in eukaryotes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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