Thermo Fisher Scientific CD253 (TRAIL) Monoclonal Antibody (N2B2), PE, eBioscience
마우스 CD253(TRAIL)을 인식하는 단클론 항체로, Flow Cytometry에 최적화되어 있습니다. PE 형광 표지로 488–561 nm 레이저에서 검출 가능하며, 0.125 µg/test로 사용됩니다. IL-2 또는 IL-15 자극 후 NK 세포의 TRAIL 발현 분석에 적합합니다.
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Thermo Fisher Scientific CD253 (TRAIL) Monoclonal Antibody (N2B2), PE, eBioscience™
Applications
- Flow Cytometry
Tested Dilution: 0.125 µg/test
Publications: View 11 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N2B2 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466056 |
Additional Formats
Product Specific Information
The N2B2 monoclonal antibody reacts with mouse TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily. TRAIL is not detected on the surface of freshly isolated T, B, or NK cells, but can be induced preferentially on CD3^- NK1.1^+ NK cells after stimulation with IL-2 or IL-15.
N2B2 inhibits IL-2- or IL-15-activated NK cell cytotoxicity against mouse fibrosarcoma L929 target cells.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested by flow cytometric analysis of mouse CD253-transfected cells. Recommended ≤ 0.125 µg/test (100 µL final volume). Cell number range: 10^5–10^8 cells/test. Antibody titration recommended for optimal performance.
Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
TRAIL is a cytokine belonging to the TNF ligand family. It preferentially induces apoptosis in transformed and tumor cells, but not in normal cells. TRAIL binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly TNFRSF11B/OPG.
Its activity may be modulated by decoy receptors that cannot induce apoptosis. Binding of TRAIL to its receptors activates MAPK8/JNK, caspase 8, and caspase 3.
TRAIL is a type II membrane protein expressed in various tissues and induces apoptosis and NF-κB activation similar to TNF and Fas ligand.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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