Thermo Fisher Scientific POLR3D Polyclonal Antibody
Rabbit polyclonal antibody targeting human POLR3D 단백질. IHC(P)에서 1:500–1:1,000 희석비로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 제품. BRCA1 상호작용 연구 및 암 관련 연구에 활용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human POLR3D (UniProt ID: P05423-1, antigen range: 87–150, antigen length: 398) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long term, store at -20°C and avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2645769 |
Product Specific Information
- Immunogen sequence:
DRQREGHGRG RGRPEVIQSH SIFEQGPAEM MKKKGNWDKT VDVSDMGPSH IINIKKEKRE TDEE - Highest antigen sequence identity:
Mouse – 98%, Rat – 98%
Target Information
This gene encodes a protein that interacts with the N-terminal region of BRCA1. It shares homology with conserved regions of BRCA1, including the N-terminal RING motif and C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in proteins regulating cell growth, including tumor suppressor and proto-oncogene products. This protein also contains three tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, suggesting that a stable complex between these proteins is critical for BRCA1 tumor suppression. It may be a target of oncogenic mutations in breast or ovarian cancer.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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