Thermo Fisher Scientific POLR3G Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000
• View 1 publication

ChIP assay (ChIP)

• Tested Dilution: –
• View 1 publication

Product Specifications

Product Specific Information

POLR3G Polyclonal Antibody detects endogenous levels of POLR3G protein.

Target Information

DNA-dependent RNA polymerase catalyzes transcription of DNA into RNA using four ribonucleoside triphosphates as substrates.
POLR3G is a peripheral component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs. It may interact with other subunits (RPC3/POLR3C, RPC6/POLR3F, RPC7/POLR3G) to facilitate RNA Pol III binding to the TFIIIB-DNA complex.
POLR3G is involved in recruitment and stabilization of the subcomplex within RNA polymerase III and may stimulate catalytic functions during initiation.
It plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, acting as a nuclear and cytosolic DNA sensor in the innate immune response.
POLR3G can recognize non-self dsDNA, transcribe it into dsRNA, and induce type I interferon and NF-κB through the RIG-I pathway (e.g., Epstein-Barr virus-encoded RNAs).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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