Thermo Fisher Scientific VGCNL1 Polyclonal Antibody
VGCNL1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. WB 및 IHC에 사용 가능하며, 인간·마우스·랫트 반응성을 보입니다. 합성 펩타이드 항원으로 제작된 비결합형 항체로, 연구용으로 적합합니다.
- 카탈로그번호
- OSV00091W-100UL
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:200–1:2,000
- Publications: View 1 publication
Immunohistochemistry (IHC)
- Tested Dilution: 1:200–1:2,000
- Publications: View 1 publication
Miscellaneous PubMed (Misc)
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from internal region of human VGCNL1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: VGCNL1.
Target Information
Nalcn is a voltage-independent, cation-nonselective channel permeable to Na⁺, K⁺, and Ca²⁺ ions. It regulates resting membrane potential and neuronal excitability. Neuropeptides such as neurotensin and substance P activate NALCN via SRC family kinase-dependent pathways. Nalcn activity is modulated by GPCRs, essential for respiratory rhythm, neonatal survival, and systemic osmoregulation. It contributes to intestinal pacemaking and neuronal excitability in substantia nigra pars reticulata.
Diseases associated with NALCN include congenital contractures of limbs and face, hypotonia, developmental delay, and infantile psychomotor retardation with characteristic facies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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