Thermo Fisher Scientific LRRFIP1 Polyclonal Antibody
Mouse LRRFIP1 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 최적화되어 있습니다. β-catenin 의존적 신호전달 연구 및 TLR 관련 염증 반응 조절 연구에 활용됩니다. 고순도 Affinity chromatography로 정제되어 안정적이며, 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific LRRFIP1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1.0 µg/mL
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of mouse LRRFIP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2690051 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
Target Information
Leucine-rich repeat FLI-I interacting protein 1 (LRRFIP1/FLAP-1) is a MyD88-interacting signal protein that mediates induction or repression of TLR signaling.
Flap-1 directly interacts with β-catenin and activates β-catenin-dependent transcription activity.
It also binds the TNF- -308 promoter polymorphism site, suggesting a role in TNF- production regulation.
FLAP-1, LRRFIP2, and FLIIH together coordinate inflammatory response after infection and may serve as novel targets in controlling agonist-induced TLR-mediated inflammatory and autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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