Thermo Fisher Scientific Tau Polyclonal Antibody

Applications

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. Its primary function is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N-terminus interacts with neural plasma membrane components, acting as a linker between both structures.

Tau localization determines axonal polarity within neurons. Short isoforms contribute to cytoskeletal plasticity, while longer isoforms aid in stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), which form neurofibrillary lesions characteristic of Alzheimer’s disease (AD).

Hyper-phosphorylation impairs Tau’s microtubule-binding ability, leading to microtubule destabilization and neuronal degeneration in AD. Multiple kinases including GSK-3β, PKA, CDK5, and casein kinase II are known to phosphorylate Tau. Hyper-phosphorylated Tau is also found in other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지