Thermo Fisher Scientific ARIH1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ARIH1, validated for ICC/IF applications. Recombinant human ARIH1 used as immunogen. Unconjugated, liquid form, antigen affinity purified. Suitable for research use in protein ubiquitination and translation st...
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Applications
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ARIH1. Recombinant protein control fragment (Product #RP-107917) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665254 |
Product Specific Information
Immunogen sequence:
NHMVCRNQNCK AEFCWVCLGP WEPHGSAWYN CNRYNEDDAK AARDAQERSR AALQRYLFYC NRYMNHMQSL RFEHKLYAQV KQKMEEMQQH N
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
E3 ubiquitin-protein ligase ARIH1 catalyzes ubiquitination of target proteins with E2 enzyme UBE2L3. Functions as an atypical E3 ligase in cullin-RING ubiquitin ligase (CRL) complexes, initiating ubiquitination of CRL substrates. Activated upon binding to neddylated CRL complexes. Involved in protein translation response to DNA damage via EIF4E2 ubiquitination. Plays a role in ISGylation of EIF4E2 and degradation of LINC complex member SUN2, influencing nuclear morphology and localization. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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