Thermo Fisher Scientific MDMX Monoclonal Antibody (OTI4B5)
MDMX 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 시료 반응성. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보관. p53 조절 관련 연구에 적합.
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Thermo Fisher Scientific MDMX Monoclonal Antibody (OTI4B5)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B5 |
| Immunogen | Full length human recombinant protein of MDM4 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724664 |
Target Information
The MDM2 protein is the primary regulator of p53 protein stability. MDMX (also known as MDM4) is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 through distinct associations with MDM2. The MDMX gene is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester it within the nucleolus, leading to increased p53 transactivation. Expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. MDMX also binds and stabilizes p73, increasing its half-life in contrast to p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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