Thermo Fisher Scientific SPIN1 Polyclonal Antibody
SPIN1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 사용 가능. 인간, 마우스, 랫에서 반응하며, PBS 기반 용액 형태로 제공. 세포주기 조절 및 종양 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SPIN1 (Accession Q9Y657), corresponding to amino acid residues A17–G67 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850718 |
Product Specific Information
Antibody detects endogenous levels of total SPIN1.
Target Information
SPIN1 (spindlin 1), also known as SPIN or ovarian cancer-related protein (OCR), is a 262 amino acid nuclear protein suggested to play a role in regulation of the cell cycle during the transition from gamete to embryo.
A member of the SPIN/STSY family, SPIN1 localizes to the interphase nucleus and mitotic chromosomes, and is modified by phosphorylation in a cell-cycle-dependent manner.
As a meiotic spindle-binding protein, SPIN1 overexpression has been shown to cause defects in mitotic spindles, leading to chromosome instability and potential tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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