Thermo Fisher Scientific CD148 Monoclonal Antibody (MEM-CD148/05), PE

Applications

• Flow Cytometry (Flow): 10 µL/1×10⁶ cells
• View 1 publication

Product Specifications

Available Formats

• Unconjugated (MA5-28592)
• APC (MA5-28590)
• Biotin (MA5-28591)
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD148, a highly glycosylated (up to 250 kDa) receptor-like protein tyrosine phosphatase expressed mainly in lymphocytes, myeloid cells, and epithelial cells.

Target Information

CD148 is a highly glycosylated transmembrane protein (~250 kDa) containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found on fibroblasts, epithelial cells, lymphocytes (B, T, NK cells), and myeloid cells (monocytes, granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-γ, playing a role in the downregulation of T cell activation. Expression can be upregulated following T cell activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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