Thermo Fisher Scientific MRP7 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:25-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human ATP-binding cassette, sub-family C (CFTR/MRP), member 10

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 40% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2635989

Product Specific Information

The antibody detects endogenous levels of total ABCC10 protein.

Target Information

The MRP family is represented by nine similar ABC transporters that have the ability to transport structurally diverse lipophilic anions and operate as chemical efflux pumps. MRP7 (multidrug resistance-associated protein 7, ATPbinding cassette sub-family C member 10) is a multi-pass membrane protein that belongs to the ABC transporter family (conjugate transporter subfamily). MRP7 is involved with the ATP-dependent transport of 17β-estradiol-D-17-β-glucuronide (E217βG). MRP7 is also probably involved in cellular detoxification through its lipophilic anion extrusion capabilities. MRP7 contains two ABC transmembrane type 1 domains and two ABC transporter domains. MRP7 likely has three isoforms. Isoform 2 is the most widely expressed, while isoform 1 is predominately expressed in the spleen.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.