Thermo Fisher Scientific DNA-PK Polyclonal Antibody
DNA-PK 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, IP 등 다양한 실험에 사용 가능. 인간, 생쥐, 햄스터, 랫트 반응성. 액상 형태로 제공되며 4°C 또는 -20°C 보관 권장.
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:250 |
| Immunoprecipitation (IP) | Assay-dependent |
| Gel Shift (GS) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human DNA-PKcs (UniProt ID: P78527-1, antigen range: 1–4128) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2300402 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and often inhibited by PI3 kinase-targeting molecules.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting formation of a transcriptional pre-initiation complex.
Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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