Thermo Fisher Scientific ST2 Polyclonal Antibody

Thermo Fisher Scientific ST2 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:500–1:2,000

Species Reactivity

Human, Mouse, Zebrafish

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide within mouse IL1RL1 aa 13–62/567.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage Buffer

PBS, pH 7.4, with 40% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage Conditions

• Store at 4°C for short term
• For long term storage, store at -20°C, avoiding freeze/thaw cycles

Shipping Conditions

• Ambient (domestic)
• Wet ice (international)

RRID

AB_2932615

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Target Information

IL-33R, also known as ST2, is a receptor for IL-33 and a member of the IL-1 receptor family.
Its extracellular domain contains three Ig-like domains that interact with the co-receptor IL-1RAcP and ligand IL-33.
Binding of IL-33 triggers association with adaptor proteins (MyD88, IRAK1, IRAK4, TRAF6), activating NF-κB and MAPK pathways and promoting cytokine release (IL-5, IL-6, IL-8, IL-13).
Two isoforms exist due to alternative splicing:

• ST2L: membrane-bound form
• ST2S: soluble form acting as a decoy to dampen IL-33 signaling

IL-33R is mainly expressed by mast cells, basophils, and eosinophils. In mice, expression is also observed in ILC2 and Th2 cells.
IL-33R signaling is implicated in immune conditions including allergies, arthritis, atherosclerosis, and sepsis.

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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.