Thermo Fisher Scientific EXOSC10 Polyclonal Antibody
EXOSC10 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, IP 등 다양한 응용에 사용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품으로 4°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 200–250 of human Exosome Component 10 (EXOSC10) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC: Epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl.
Exosome component 10 (EXOSC10), also known as autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients.
EXOSC10 is strongly enriched in the nucleolus, with a small amount found in the cytoplasm, supporting the existence of a nucleolar RNA exosome complex form.
As a putative catalytic component of the RNA exosome complex with 3'→5' exoribonuclease activity, EXOSC10 participates in various cellular RNA processing and degradation events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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