Thermo Fisher Scientific PIP5K1C Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PIP5K1C (AAH11138.1, 1 a.a. approximately 206 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PIP5K1C,uniProtId:O60331-1,ncbiNodeId:9606,antigenRange:1-668,antigenLength:668,antigenImageFileName:H00023396-D01P_PIP5K1C_O60331-1_Rabbit.svg,antigenImageFileNamePDP:H00023396-D01P_PIP5K1C_O60331-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MTPRHPLFTS RRPPAQPTRC ARKAPAVEKP DPSPRSPART HTPREQPLHS AQERGRPSSG TGQPRGSQHP SGQAHVGSSL RAQRVCPALG SDLGLSSQPG AHLLAPGIHP SAPALSLRRT PSRHPPGRQG QRSEGVSGTW MASRDRGIVI SKAQPPEATP VLPGSPRVAL PRALAPETPR ACGVTRSSRC GPGRAAPRPG QPPSAE

Target Information

PIP5K1C lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with -beta-catenin and increases -beta-catenin activity downstream of growth factor stimulation. PIP5K1C expression and kinase activity enhance -beta-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitation of RhoA GTPase and integrin activation by chemo attractants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.