Thermo Fisher Scientific KPNA2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: The peptide used to generate this antibody is available for purchase (GTX26036-PEP).
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

The import of proteins into the nucleus is a process that involves at least two steps:

1. Energy-independent docking of the protein to the nuclear envelope.
2. Energy-dependent translocation through the nuclear pore complex.

Imported proteins require a nuclear localization sequence (NLS), which generally consists of a short region of basic amino acids or two such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import include the Xenopus protein importin and its yeast homolog SRP1, which bind to the NLS.

KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in VJ recombination.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.