Thermo Fisher Scientific ATGL Monoclonal Antibody (494702)
ATGL 단백질을 특이적으로 인식하는 Mouse monoclonal antibody로 Western blot과 Flow cytometry에 사용 가능. 인간 시료 반응성. 단백질 A/G 정제, 동결건조 형태로 제공되며, PBS 및 5% trehalose buffer에 용해 가능. 연구용 한정.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 494702 |
| Immunogen | E. coli-derived recombinant human PEDF R/PNPLA2 (Val162–Thr332) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606183 |
Product Specific Information
- In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse PEDF R is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Lipolytic enzymes are essential for mobilizing fatty acids from triglyceride stores in adipose tissue. Dysfunctional lipolysis affects energy homeostasis and may contribute to obesity and insulin resistance.
Previously, hormone-sensitive lipase (HSL) was recognized as the main triglyceride-hydrolyzing enzyme in mammalian adipose tissue. However, adipose triglyceride lipase (ATGL) has been identified as another key enzyme catalyzing the initial step in triglyceride hydrolysis.
ATGL is highly expressed in adipose tissue of both mice and humans, exhibits high substrate specificity for triacylglycerol, and associates with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity, indicating that ATGL and HSL work together to catabolize stored triglycerides.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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